During a physical examination of the patient, the pulse rate is determined, since with aplasia, most often it is speeded up. First, the doctor takes a history and then conducts a physical examination of doxycycline. If bone marrow aplasia is suspected, the following examinations are prescribed: Blood test. Histological examination. cytogenetic study.
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Cytogenetic testing may be required to rule out leukemia or myelodysplastic syndrome and other causes. Possible deviations in the number, as well as in the structure of chromosomes, can be detected using this research method. The acquired form of the disease is usually not characterized by defects in the genetic material. Detection of changes in chromosomes most likely indicates the presence of myelodysplastic syndrome.
If the factor causing anemia is known - radiation, chemicals, drugs - it is recommended to eliminate it. Treatment depends on the severity of the disease. Therapy for severe and very severe aplasia of the hematopoietic system is no different.
With a mild form of aplasia, expectant therapy is recommended: the patient should regularly visit a doctor and undergo routine examinations.
The life expectancy of these patients does not decrease even in the absence of Doxycycline.
Hematopoietic stem cell transplantation. immunosuppressive therapy. supportive therapy.
If there is a donor in the family (eg siblings), the bone marrow transplant should be performed as soon as possible. A long wait before transplantation and a large number of blood transfusions can worsen the patient's initial condition. If a suitable donor is not found, immunosuppressive therapy is prescribed. Preliminary planning of Doxycycline in a specialized center is absolutely necessary for bone marrow aplasia.
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After immunosuppressive therapy, about 30% of patients experience a relapse of the disease. About 20% of patients develop acute myeloid leukemia or paroxysmal nocturnal hemoglobinuria. If in the first 3-6 months after the administration of the drugs there is no noticeable improvement in the composition of the blood, or after successful therapy, aplastic anemia recurs again, stem cell transplantation is necessary.
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The chances of a patient recovering with timely treatment are quite high, although this is a life-threatening condition. Allogeneic transplantation of hematopoietic stem cells leads to the recovery of 80-90% of patients with hypoplasia in the bone marrow. A cell transplant from an unknown donor can also cure patients with bone marrow disease. However, many children and adolescents (about 20-30%) still develop serious and sometimes fatal complications.